Bai Jerbai Wadia Hospital For Children successfully treats a 14-year-old Titwala boy with rare Pancreatic Neuroendocrine Tumor

By / 2 months ago / News Update / 42 Comments
Bai Jerbai Wadia Hospital For Children successfully treats a 14-year-old Titwala boy with rare Pancreatic Neuroendocrine Tumor

The tumor was producing a hormone – adrenocorticotropic hormone (ACTH) that stimulated the adrenal gland to produce more cortisol, he also developed Cushing’s disease

Neuroendocrine tumours (NET) are considered rare tumors, and the current incidence is reported to be about 6 cases in 100 000 in adults and about 2.8 cases per million in the paediatric age group. Paediatric pancreatic tumors are even rare, with an incidence of 0.46 per million (under 30 years of age).

Pancreatic neuroendocrine tumors (PNETs), is agroup of endocrine tumorsarising in the pancreas, are the rarest representing 1-2% of all pancreatic tumors.A team led by Dr Rajesh Joshi, Professor, Division of Pediatric Endocrinology, BJWHCgave a new lease of lifeto a 14-year-old boy from Titwala, Thane district, who suffered from this rare tumor, with the help of surgery, chemo, and radiation. Now, the patient who was unable to go to school wishes to resume school after 7 months.

At 14, when other children of Mandar Anant Waghmare’s age would go to school, Mandar would just be at home owing to hyperpigmentation.  Soon, it became a matter of concern for his family as he stopped venturing out of the house. This shook him and resulted in low self-esteem and anxiety. Moreover, his health deteriorated further when he also exhibited other alarming symptoms like abdominal pain. His family ran from pillar to post to help me get back on track, and fortunately, the patient was referred to BJWHC wherein the doctors saved his life.

Dr Rajesh Joshi, Professor, Division of Pediatric Endocrinology, BJWHC, said, “Mandar was admitted in April 2018 with complaints of hyperpigmentation, abdominal pain, high blood pressure, and headache. After examining him, it was thought to be a problem with the adrenal gland (these are small glands in the abdomen). But, hormonal changes were noted and his cortisol was high (49 ug/dl). Usually, when a child visits the hospital with the problem of skin pigmentation, the cortisol is low. Further, his CT scan revealed that he suffered from Pancreatic Tumorlater confirmed on biopsy as PNET”. 

Dr. added, “It was a rare poorly differentiated grade 3tumor of the pancreas. Due to the aggressive nature of this tumor, the two-year survival rate is approximately 60% and the five-year survival rate is only 16%.”The tumor was producing one hormone called adrenocorticotropic hormone (ACTH) which stimulated the adrenal gland to produce more cortisol. The ACTH is normally produced in the pituitary gland. But in this patient, this tumor was surprisingly producing a high amount of ACTH instead of the pituitary gland producing it and this is called Ectopic ACTH syndrome (EAS). This results in hyperpigmentation and hypercortisolismHence, the patient underwent tumor removal surgery in November 2018. The surgery lasted for 6 hours. The patient was admitted in PICU for 5 days and was discharged within 7 days of surgery.”

After surgery, his hormonal parameters return to normal. “But after 6 months, he developed a condition called cushings disease (it occurs when your body is exposed to high levels of the hormone cortisol for a long time), metastasis in the abdomen, and hyperpigmentation, and the disease relapsed.  With the help of the oncology team, he was given 24 cycles of radiation, completed4 months ago, and 6 cycles of chemo, completed a month ago. The patient’s cushings features disappeared which was confirmed by hormonal tests. However, he needs to follow up lifelong for a relapse,” underscored Dr Joshi.

A teary-eyed Mandar Waghmare stated, “Last year when I was in 8th standard, after the last paper of my final examination, I was admitted to the hospital, owing to stomach pain and hyperpigmentation. After surgery, I was fine, but the disease recurred. My family was worried but they were there throughout the thick and thin. In 2019, I underwent treatment and am recovering now. I have been advised to cut down on junk and non-veg food. I want to thank the doctors for helping me start the new innings of my life. I have missed school for more than 7 months, so I intend to resume school, and meet my friends.”

Dr Minnie Bodhanwala, Chief Executive Officer of the Wadia Hospitals said, “The hospital is always committed to serve the paediatric patients, and has always been at the forefront in introducing cutting edge medical technology, expertise, and equipment. It strives to make affordable healthcare for all, a reality. The hospital works relentlessly, and organizes drives, campaigns, and activities to spread awareness regarding various ailments.”

What do you need to know?

  1. Pediatric NET is rare, seen usually in gut and lung. Pancreatic NET are rarest have an incidence of <0.1 per one million persons, and secretion of ectopic adrenocorticotropic hormone (ACTH) is even rarer.
  2. The overall incidence of Cushing syndrome is 2 to 5 new cases per million people per year, with only 10% of the new cases each year occurring in children.
  3. A recent multicenter retrospective study over a 20 year period identified 10 cases of ectopic ACTH secreting tumor presenting before the age of 20 years.

Sahil Saini

Sahil Saini

The author didn't add any Information to his profile yet.


  • tryebony24. Feb, 2020

    I’ve been exploring for a little bit for any high quality articles or weblog posts on this kind of area . Exploring in Yahoo I ultimately stumbled upon this web site. Studying this info So i am satisfied to exhibit that I’ve a very just right uncanny feeling I found out just what I needed. I most unquestionably will make sure to don’t omit this site and provides it a glance on a relentless basis.

  • tagass24. Feb, 2020

    I want to convey my respect for your generosity giving support to men and women who should have help with this particular area of interest. Your very own commitment to passing the solution all around was quite effective and have in most cases empowered individuals just like me to arrive at their aims. Your entire helpful guide can mean a lot to me and even further to my fellow workers. Thanks a ton; from everyone of us.

  • plentyshows24. Feb, 2020

    You could definitely see your skills in the work you write. The world hopes for even more passionate writers like you who are not afraid to say how they believe. Always go after your heart.

  • plentyshows24. Feb, 2020

    You are a very smart person!

  • housewiveshd24. Feb, 2020

    I got good info from your blog

  • favlive24. Feb, 2020

    I have learn some good stuff here. Definitely price bookmarking for revisiting. I wonder how a lot attempt you put to make this kind of great informative site.

  • liveviolet24. Feb, 2020

    Thank you for sharing with us, I conceive this website truly stands out : D.

  • liveviolet24. Feb, 2020

    Hey! I could have sworn I’ve been to this blog before but after checking through some of the post I realized it’s new to me. Anyhow, I’m definitely delighted I found it and I’ll be bookmarking and checking back often!

  • camabi24. Feb, 2020

    Good – I should certainly pronounce, impressed with your website. I had no trouble navigating through all tabs and related information ended up being truly simple to do to access. I recently found what I hoped for before you know it in the least. Reasonably unusual. Is likely to appreciate it for those who add forums or something, website theme . a tones way for your customer to communicate. Nice task.

  • 18flirt24. Feb, 2020

    I wanted to thank you for this great read!! I definitely enjoying every little bit of it I have you bookmarked to check out new stuff you post…

  • ethivido24. Feb, 2020

    buy cialis legally canada cialis online order reliable place buy cialis

  • 18flirt23. Feb, 2020

    I have recently started a blog, the info you offer on this site has helped me greatly. Thank you for all of your time & work.

  • check these guys out22. Feb, 2020

    Its superb as your other blog posts : D, thankyou for putting up.

  • ethivido20. Feb, 2020

    buy viagra no prescription canada cialis without a doctor’s prescription cheap viagra for sale in the uk

  • read the article19. Feb, 2020

    I’m still learning from you, while I’m trying to reach my goals. I certainly liked reading all that is written on your blog.Keep the stories coming. I enjoyed it!

  • Royal CBD gummies18. Feb, 2020

    Major thanks for the article post. Cool.

  • ethivido17. Feb, 2020

    can you buy cialis online cialis erection penis cheap cialis next day delivery

  • ethivido14. Feb, 2020

    buy cialis online generic cheapest cialis viagra online pills

  • doctors responsibilities13. Feb, 2020

    After study a few of the blog posts on your website now, and I truly like your way of blogging. I bookmarked it to my bookmark website list and will be checking back soon. Pls check out my web site as well and let me know what you think.

  • try this web-site12. Feb, 2020

    I’m still learning from you, while I’m trying to reach my goals. I absolutely liked reading all that is written on your site.Keep the tips coming. I enjoyed it!

  • Robertbroog10. Feb, 2020

    buy viagra super active online buy viagra cheap usa cheap generic cialis no prescription

  • Robertbroog04. Feb, 2020

    cialis malaysia where to buy cheap viagra professional popular pills online compra cialis italy

  • Chinese convicts executed after stadium trial02. Feb, 2020

    I’m extremely impressed along with your writing abilities as smartly as with the format on your blog. Is this a paid subject or did you modify it your self? Anyway keep up the nice high quality writing, it is rare to look a great weblog like this one nowadays..

  • trump kim jong un the notebook02. Feb, 2020

    Nice post. I learn something tougher on completely different blogs everyday. It will at all times be stimulating to read content from other writers and apply somewhat something from their store. I’d choose to use some with the content on my blog whether or not you don’t mind. Natually I’ll offer you a link in your internet blog. Thanks for sharing.

  • bitcoin crash now02. Feb, 2020

    Appreciating the dedication you put into your website and detailed information you present. It’s good to come across a blog every once in a while that isn’t the same out of date rehashed material. Excellent read! I’ve bookmarked your site and I’m including your RSS feeds to my Google account.

  • sse composite index01. Feb, 2020

    Whats up very cool blog!! Guy .. Beautiful .. Wonderful .. I’ll bookmark your website and take the feeds additionally…I’m satisfied to find a lot of helpful info right here in the put up, we need work out extra techniques in this regard, thanks for sharing. . . . . .

  • Robertbroog01. Feb, 2020

    buy cialis genuine generic viagra cheap uk cheap viagra sale online

  • Waynedaf28. Jan, 2020

    Cialis cialis lowest price 20mg tiujana cialis

  • Waynedaf23. Jan, 2020

    Cialis how often to take 10mg cialis cialis for daily use

  • Norah Sane22. Jan, 2020

    Hello.This post was extremely motivating, especially since I was looking for thoughts on this issue last week.

  • Waynedaf20. Jan, 2020

    Cialis generic cialis tadalafil fastest delivery of cialis buying online

  • Waynedaf17. Jan, 2020

    Cialis cialis generic availability cialis for daily use

  • Mandela Carrey15. Jan, 2020

    Hello ! This is a remarkably compelling advise that you made

    Keep it up ! Luxury interior design companies London

  • KotakiElstongow14. Jan, 2020

    order is in canada online

    3432 is a che et

  • Maria Escobarai14. Jan, 2020

    This is a same signal post. Thanks instead of posting this.

    What do you think almost my website: servicii creare site web

  • John Canioeu13. Jan, 2020

    This is a to a great extent respected post. Thanks for posting this.

    What do you believe nearby my website: creare site bucuresti

  • Peterwal13. Jan, 2020

    Hello, blame you in judge to facts! cialis at a discount price
    viagra for men

  • Cristi Andye13. Jan, 2020

    This is a to a great extent respected post. Thanks for posting this.

    What do you believe about my website:

  • Stevavette11. Jan, 2020

    Levitra Lowest Price Viagra Generico Yahoo Amoxicillin Joint Replacement [url=]cheapest cialis 20mg[/url] Want To Buy Doxycycline

  • EverettJag09. Jan, 2020

    Hello, recognition you for word! canadian pharmacy viagra I repost in Facebook.
    viagra cost

  • what is cialis used for03. Jan, 2020

    Hello, recognition you looking for information! I repost in Facebook

  • Abogados De Accidentes Carro Mesquite TX02. Jan, 2020

    I just like the valuable info you provide on your articles. I will bookmark your weblog and check again right here regularly. I am reasonably sure I’ll be told a lot of new stuff proper here! Best of luck for the next!

Leave a comment

Your email address will not be published. Required fields are marked. *