Munir Ahmad, Zh.M.Umarov. F.Kh. Abboskhonova

Tashkent medical academy

Purpose: to conduct a comparative assessment of the results of regulated serological tests obtained in blood tests of patients with latent late syphilis

Materials and methods: the medical records of 123 patients with a newly diagnosed case of latent late syphilis in the Tashkent Regional Dermatovenerologic Dispensary at 2016 to 2021 were studied. The analysis of the results of blood tests of patients using non-treponemal (RMP/RPR) and treponemal (RPHA, ELISA), RIFabs, RIF, RIBT) serological tests was carried out.

Results: it was found that in the study of the blood of patients with latent late syphilis, the largest number of positive results were obtained in treponemal serological tests, such as ELISA (100%), TPHA (100%) and RIFabs (100%). The largest number of negative results were observed in non-treponemal (RMP/RPR) serological tests – in 80 (72.7%) patients, while sharply positive (4+) results of these tests were obtained only in 4 (4.3%) patients. Comparative analysis of the results of blood tests in patients with latent late syphilis obtained using treponemal serological tests showed that the largest number of sharply positive (4+) results was noted in the TPHA test (in 57.9% of cases). Negative results of treponemal tests were obtained in blood tests using RIF and RIBT (in 11.7% and 9.8% of cases, respectively). In addition, weakly positive results prevailed in the RIF – in 45 (34.7%) of the total number of patients.

Conclusions: the analysis of the results of regulated non-treponemal (RMP/RPR) and treponemal (RPHA, ELISA (RIF, RIBT)) serological tests made it possible to evaluate the diagnostic effectiveness of these methods in the study of the blood of patients with latent late syphilis. The data presented indicate that the most reliable tests for detecting patients with latent late syphilis are treponemal tests: ELISA, RPHA, and RIF. Given the relevance and importance of early detection of patients with latent syphilis, it is advisable to use treponemal tests as screening methods for a mass examination of the population, which will allow more effective control over the spread of syphilitic infection in the Tashkent region.